Accuracy of translation on ribosome could be provided by a resonance of intramolecular oscillations in tRNA molecules
نویسنده
چکیده
X-ray data indicate that complexes of ribosomes with cognate and near cognate tRNAs are very similar structurally, and this was the ground for a suggestion that the ribosome discriminates correct codon-anticodon pair because of its higher stability. Here an alternative explanation of kinetic proofreading is suggested, and intramolecular oscillations in tRNAs play a keystone role in it. Resonance of the oscillations allows the cognate codon-anticodon pair to be conserved due to fast energy transfer to other part of the tRNA molecule. This mechanism can potentially discriminate correct pair from an incorrect one even if they have similar stabilities.
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